The EXPErimental medicine Route To Success in ALS (EXPERTS-ALS) is designed to accelerate progress towards highly-effective drug therapies for amyotrophic lateral sclerosis (ALS, the commonest form of motor neurone disease, MND). The study will screen candidate drugs in those living with ALS, more quickly identifying those with signals of likely clinical benefit, that may then be prioritised for testing in larger placebo-controlled trials.
EXPERTS-ALS is led by Professor Chris McDermott at the University of Sheffield and Professor Martin Turner at the University of Oxford.
It involves 11 MND centres around the UK and is being sponsored by Sheffield Teaching Hospitals NHS Foundation Trust.
It is a flagship study within the broader portfolio of the UK MND Research Institute.